U.S. State Department officials say Secretary of State Colin Powell has resigned.
The officials, speaking on condition of anonymity, say Mr. Powell submitted his resignation to President Bush on Friday.
They say Mr. Powell indicated he will remain until the president names a successor.
Mr. Powell has served as Secretary of State since 2001. During his military career, he rose to the rank of four-star general and served as chairman of the U.S. Joint Chiefs of Staff.
Meanwhile, the White House says it will announce a total of four resignations from Mr. Bush's cabinet Monday, though spokesman Scott McClellan declined to say who was leaving.
Information for this report is provided by AP, AFP and Reuters.