University scientists in the United States have taken what they say is an important step in the effort to end malaria. At Johns Hopkins Malaria Research Institute, scholars recently identified a sugar in mosquitoes that helps explain, for the first time, the mechanism of the malaria parasite invasion.
The finding could be a key element for a vaccine development in the the fight against malaria.
At Johns Hopkins University.
"I am removing the males only, because the males are not important to our research work. (why?). Males do not blood feed, they feed on sugar only."
Researcher Rhoel Ramos Ding-lasan dissects the type of mosquito that transmits the malaria parasite that kills about three million people each year around the world. Experts report the understanding and control of the malaria parasite is one of the most serious scientific challenges of all time.
"These are cages of adult Anopheles mosquitoes."
This week, scientists at the Johns Hopkins Malaria Research Institute announced they identified a sugar in mosquitoes that the malaria-causing parasite [Plasmodium falciparum] needs. The sugar is essential in the parasite's movement within a the midgut section of a mosquito's body.
"This is the mosquito gut, filled with blood"
Professor Marcelo Jacobs-Lorena is the senior author of the research. He says that by stopping the production of that sugar, the parasite dies.
"The second step which was a definite proof was to -- by genetic means -- interrupt sugar production. So we infected those impaired mosquitoes with the parasite and we found that indeed the parasite was unable to traverse the midgut."
But the scientists say it is difficult to treat the mosquitoes in nature. They suggest a human vaccination with antibodies that would block sugar production in the mosquito. When a mosquito feeds on human blood, it would ingest the antibody. The new finding brings scientists one-step closer to developing effective malaria vaccines.
"The best hope we have is that we have a combination of transmission blocking vaccine that the antibody works in the mosquito stage, combined with infection blocking, so that people are protected."
Now 20 years into his work, Jacobs-Lorena says it will take ten to 15 more years to find practical applications. Still, he says this new study -- along with research on mosquito gene modication -- puts scientists closer every day to eradicate malaria.
